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This is for anyone who is considering using weight loss injections through the Kingston Healthy Weight Centre (KHWC).
KHWC offers weight loss medicines which are approved by NICE for prescription in NHS specialist weight management clinics. The medicines currently approved for prescription are detailed below. Note these are subject to change as and when NICE guidelines are updated (and subject to availability from manufacturers).
NICE guidelines make specific recommendations about how these medicines can be prescribed as follows:
- Suitability for the patient, based on specific BMI thresholds and the presence of weight related health conditions. Your endocrinologist (a specialist in hormone related diseases) will follow these guidelines and advise which medicines would be appropriate for you.
- Use of these medicines only if accompanied by a reduced calorie diet and increased physical activity.
Weight loss medicines that KHWC offers
The main category of medicines currently approved for prescription by specialist weight management clinics are called ‘GLP 1 receptor agonists’ (GLP 1RAs).
GLP 1RAs act like the hormone GLP 1 which we produce naturally in our bodies and which affects appetite and food intake.
These medicines do the following:
- Help the body produce insulin (a hormone that enables your body to use glucose for energy).
- Reduce the amount of excess glucose (sugar) being released by your liver.
- Slow the rate at which your stomach digests and empties food, thus making you feel fuller.
- Reduce your appetite, resulting in reduced food intake.
Some of the medicines also act like other hormones in our bodies that affect your appetite and help to keep your blood sugar stable.
How to take weight loss medicines
GLP 1RAs come in pre-filled pens that you use to inject yourself into your abdomen, thigh or upper arm once a week.
We initially prescribe you with a low dose. We increase this gradually to a recommended maintenance dose over several weeks, to minimise side effects.
How much weight you will lose
In research studies, people taking the maintenance dose of GLP 1RAs and following a reduced calorie diet combined with increased activity, lost an average of around 15% to 20% of their body weight. They lost this weight over about 16 months.
Action | Period of time | Average weight loss |
All of these combined:
|
16 months | 15% to 20% of body weight |
Note this is an average, so some people lost more than this and some people lost less.
Important
Current NICE guidelines say that the GLP 1RA injections can be prescribed for 2 years. Research shows that when the medicines are stopped people are likely to regain some weight.
NICE Guidelines also state that the medicines should be discontinued if you lose less than 5% of your body weight in 6 months as this would mean the medicines are not working for you.
Dietary recommendations with weight loss injections
It is important to follow a healthy diet and include regular exercise while you are using weight loss injections. This helps you to achieve the best weight loss results and improve your overall health.
GLP 1RA medicines can significantly reduce your appetite and help you to lose weight, but research shows that weight regain is common once the medicine is stopped.
Making lifestyle changes and establishing healthier habits can help you maintain your weight loss in the long term. |
Following a healthy diet and increased exercise can help to make sure the weight you lose is mostly fat and reduce the amount of muscle you lose.
This is important to maintain your strength and mobility and can help you to avoid weight regain in the future.
Studies show that no single type of ‘diet’ or dietary intervention has been found to work best with weight loss injections. These studies indicate that ‘diets’ (such as low carb or intermittent fasting) are no more beneficial for losing weight while using the injections than a regular, healthy balanced diet.
Research does show that healthy, balanced dietary patterns such as the Mediterranean diet can help you lose weight and improve health outcomes.
The Mediterranean diet is based on eating plenty of fruits and vegetables, lean protein and healthy fats (see healthy eating section below). It has been found to be beneficial to people with heart conditions, type 2 diabetes and inflammatory conditions such as arthritis.
By promoting feelings of fullness, weight loss medications can support healthy dietary choices, as you will be less likely to feel hungry or crave high calorie, low nutrient foods. This can help with weight loss and improve overall health.
Weight loss injections may reduce your appetite so that you lose weight, but if you have a diet high in unhealthy foods this will not improve your overall health. It will also increase the chance of weight regain once the medicine is discontinued.
Healthy, balanced eating
We strongly advise you to follow a healthy, balanced diet while you are taking GLP 1RA injections.
Start to gradually make changes before you begin your injections. This can help to make it easier for you to follow healthy eating patterns when you start the injections and to continue them when the medicines are stopped.
Try to focus on foods rich in nutrients. Limit sugary and high fat foods.
For most people, a healthy balanced diet means having the following.
- Three main meals a day.
- Include a portion of protein, carbohydrate, fat and plenty of fruits and vegetables in each meal.
- Adequate fluid intake.
A balanced meal for weight loss looks like this:
Protein
Protein is essential for maintaining muscle mass whilst losing weight.
It is important to maintain your muscle mass so that your metabolism stays high and you maintain your strength and ability to do your usual daily activities.
Protein foods also keep you fuller for longer. If you eat plenty of protein with your meals this can reduce the need for snacks in between.
Aim for 70g to 100g of protein per day. Include at least one portion of protein at every meal.
Examples of foods high in protein include:
- fish, seafood
- meat
- eggs
- tofu, tempeh
- beans, lentils, peas, chickpeas
- yoghurt, cheese.
Further sources of protein are listed in the Guide to the protein content of some everyday foods section at the end of this leaflet.
1 portion of protein = |
A palm sized piece of chicken or fish |
If you have snacks between meals, include a source of protein here too. Some protein rich snack ideas are:
- 1 tablespoon of nuts such as almonds, with some fruit.
- 1 tablespoon of reduced fat houmous, with some carrot sticks.
- 1 hardboiled egg, with some tomatoes.
- 2 tablespoons of low fat cottage cheese with a rye cracker.
- 1 small pot of fat free Greek yogurt.
- 1 teaspoon peanut butter, with some apple.
Starchy carbohydrates
Choose starchy carbohydrates that are high in fibre.
Examples of starchy carbohydrates include wholegrains and brown carbohydrates like brown bread and brown rice. They help you feel fuller for longer and provide you with longer lasting energy. These carbohydrates also help improve your digestion by providing plenty of fibre.
Examples of high fibre starchy carbohydrate foods include:
- brown rice
- brown pasta or noodles
- bulgar wheat
- wholegrain couscous
- brown bread
- sweet potatoes
- white potatoes with their skins on
- oats
- quinoa.
Healthy fats
Include healthy fats with your meals.
These healthy fats are called ‘unsaturated fats’. They are beneficial for our overall health, providing essential nutrients, reducing inflammation levels and reducing your risk of heart disease.
Examples of healthy fats include:
- olive oil
- rapeseed oil
- avocado
- nuts and seeds
- oily fish, such as salmon and mackerel (these are classed as protein sources but they also contain healthy fats).
When using oils in cooking or on your foods, use small amounts as oils are high in calories. We recommend a maximum of about 1 teaspoon per meal.
Try and limit less healthy ‘saturated fats’ such as butter, ghee, coconut oil, lard, palm oil. These are also found in foods such as pastries, biscuits, cakes, fast food and takeaways and fatty or processed meats (such as salami, bacon, sausages).
Fruit and vegetables
Include a variety of fruits and vegetables, with your meals and in between as snacks. Aim to have at least 5 portions of vegetables or fruit per day.
Fruit and vegetables provide essential vitamins, minerals, antioxidants and fibre to support your immune system, help avoid constipation and improve your overall health.
Try and eat a variety of fruits and vegetables across a week, aiming for different colours and types.
All fruit is ok to have including fresh, frozen, dried or tinned in juice.
1 portion of fruit = | 1 portion of vegetables = |
One small handful (1 tablespoon if it is dried fruit) |
Two handfuls |
Aim to include 2 to 3 portions of low fat dairy per day.
Dairy foods are a good source of protein and calcium which is important for strong bones and teeth.
If you prefer to use dairy alternatives, make sure they are fortified with calcium and ideally other nutrients such as iodine and vitamin B12.
1 portion of dairy or alternatives = |
A small glass (200ml) skimmed or semi skimmed milk or A small glass (200ml) unsweetened soya milk. (Soya milk is higher in protein than other dairy alternatives such as oat milk or almond milk) or 1 small pot or 4 tablespoons low fat yogurt (no added sugar) or A small matchbox size (25g) cheese (choose reduced fat versions). |
Fluids
Stay hydratedby drinking plenty of water throughout the day. Adequate hydration supports digestion, overall wellbeing and can help to manage potential side effects of weight loss injections.
Signs and symptoms of dehydration to watch out for include decreased urine, dark coloured urine, dizziness, headaches, lack of concentration, dry mouth or lips.
Aim for at least 2 litres of fluid per day.
- Water and sugar free drinks all count towards your fluid intake.
- Alcohol does not count and can increase the risk of dehydration.
- Limit fruit juice and smoothies to a total of 150ml a day as these contain a lot of sugar.
Tips to keep hydrated:
- Sip water regularly through the day.
- Carry a reusable water bottle with you when you go out.
- Set a timer on your phone to remind you to have a drink.
- Drink more fluids than usual in hot weather or when you are active.
- If you do not like to drink plain water, some fresh fruit and mint in the water can add flavour.
Fibre
Keep fibre intake high.
A diet rich in fibre can help ease constipation which you may experience with weight loss injections. Fibre also helps promote feelings of fullness and has been shown to reduce the risk of some illnesses such as heart disease.
Examples of high fibre foods include:
- Oats and higher fibre breakfast cereal. Look for the ones labelled as ‘wholegrains’.
- Wholemeal or granary breads, or higher fibre white bread.
- Wholegrain crackers such as rye crackers and oatcakes.
- Wholewheat pasta, bulgur wheat or brown rice.
- Potatoes with their skins on, such as a baked potato or boiled new potatoes.
- Beans, lentils and other legumes such as chickpeas.
- Vegetables. Fresh, frozen or tinned (without added salt) are all good choices.
- Fruit. Fresh, frozen, dried or tinned (in juice rather than syrup).
- Nuts and seeds.
Processed foods
Avoid eating a lot of processed foods.
There are a few foods we recommend you limit eating. This does not mean you can never eat these foods, but try to eat them less and in small portions.
Do your best to minimise your intake of processed foods. They are often low in fibre and high in saturated fat, sugar, salt and calories that do not help to improve your health.
Examples of these types of food to limit include:
- pre made microwaveable foods and meals
- sugarcoated cereals
- cakes and biscuits
- pastries
- fast food and takeaways
- crisps
- sweets
- fizzy drinks.
Added sugar
Do your best to reduce the amount of foods with added sugars, such as sweets and chocolate, desserts and sugary yogurts, cakes, pastries and biscuits.
Watch out for drinks that contain a lot of sugar and calories. These should also be limited. Drinks to limit include:
- fizzy drinks
- fruit juice
- milkshakes
- some coffees and hot drinks flavoured with syrups.
Extreme dieting
There is no need to cut out entire food groups or follow extreme diets while you are on weight loss injections. Examples of extreme diets include shake diets, cutting out carbohydrates completely, keto or intermittent fasting.
Instead, focus on balanced, nutritious meals that nourish your body and support your health improvement goals.
How much to eat if you are using weight loss injections
There’s no set calorie target whilst taking GLP 1Ras.
In studies, people who lost weight were eating 1200 to 1500 calories per day for women and 1500 to 1800 calories for men.
The quantity of calories that you need to lose weight will be individual to you.
It is likely that your calorie intake will fall whilst on weight loss injections, without you needing to count calories.
GLP 1RAs trigger your body to send signals to the brain to lower appetite and reduce hunger and this helps you to eat fewer calories.
Overeating on weight loss injections can increase side effects such as bloating, cramping and even vomiting.
We recommend you record what you are eating and drinking from time to time. Studies show that people who recorded what they were eating lost most weight and were able to resist more weight gain. |
Recording your intake can help you to check that you are:
- eating regular meals
- including enough protein, fruits and vegetables
- drinking enough fluid
- avoiding extra calories that might reduce your weight loss or lead to weight gain.
It can also help you to identify any patterns of eating in response to your emotions, such as stress, that may be unhelpful for weight loss.
You do not have to record your intake forever, but it can be useful, especially for the first few weeks when you start taking the injections. We recommend you do it for a few days every now and then, or if you start to regain weight.
You can record your intake, and your activity levels, using apps, or you can fill in a food diary. Ask us for our Food and Mood diary.
As you will be consuming less food and fewer calories than before, there is a slight increased risk of developing nutrient deficiencies which can lead to malnutrition over a longer period.
You can reduce this risk by following a balanced diet with regular fruits and vegetables, protein, and some healthy fats.
We recommend you take a complete A to Z multivitamin and mineral supplement, particularly if your appetite is significantly reduced.
Managing side effects of weight loss injections
As with all medicines, there are potential side effects of weight loss injections. For most people, these side effects settle down a few weeks after starting weight loss injections.
Some people are not able to tolerate the medicines so they have to stop taking them.
Important
If your side effect symptoms persist on the lowest dose, then weight loss injections may not be suitable for you.
The most common side effects of GLP 1RA medicines include:
- nausea
- vomiting
- burping
- constipation
- diarrhoea
- dizziness
- tiredness
- gastrointestinal (stomach) discomfort
- reflux (stomach acid travels out of the stomach back into the oesophagus or food pipe)
- hypoglycaemia (low blood sugar) when used in combination with some diabetes medicines such as insulin or sulfonylureas.
Other less common but serious side effects include:
- gallstones
- pancreatitis (inflamed pancreas)
- increased heart rate
- altered taste
- changes in vision.
Some weight loss medicines have also been associated with thyroid lumps and cancer, particularly medullary thyroid cancer. These risks are based on studies in rodents (rats and mice) but have not been seen in studies of primates (eg monkeys and apes) or humans.
Tell your hospital doctor or GP if you develop a lump or swelling in the neck, hoarseness, trouble swallowing or shortness of breath whilst using weight loss injections.
For most people the side effects are mild and reduce over time.
Contact the KHWC team or come to Kingston Hospital Emergency Department (A&E) if symptoms persist or become severe.
Severe symptoms include:
- severe abdominal pain that will not go away
- vomiting or diarrhoea that does not stop
- yellowing of the skin or eyes
- pale grey or light coloured stools (poo)
- changes in your vision.
As with most medicines, weight loss injections can cause an allergic reaction in some people.
Symptoms can be mild or serious and include:
- skin rash
- itching
- flushing
- swelling under your skin, typically in your eyelids, lips, hands, or feet
- swelling of your mouth, tongue, or throat, which can make it hard to breathe.
Call 999 immediately to go to your nearest Emergency Department (A&E) if you experience severe reactions such as difficulty breathing or there is a swelling of your face, tongue or throat. |
General tips
- Try to inject yourself with the medicine at the same time and day each week so your body has a regular interval between each dose.
- Stay hydrated. Sip water through the day if you experience nausea, vomiting or diarrhoea.
- It may also help to eat smaller meals more regularly, eat slowly and avoid anything that smells or tastes too strong.
- Avoid eating late at night as this can worsen symptoms such as reflux, nausea and bloating.
Nausea, vomiting and heartburn
- eat small, plain meals
- avoid greasy, fatty, and spicy foods
- drink ginger tea or eat foods containing ginger
- eat slowly
- avoid strong smelling foods
- stay hydrated
- sip cold water or other clear fluids (such as squash)
- avoid fizzy or caffeinated drinks and alcohol
- get plenty of fresh air
- sit upright after eating and avoid eating just before bedtime
- an over the counter antacid medicine can also help.
Good hydration is key to these and other symptoms. If your urine turns a dark colour, or you feel lightheaded, this may be a sign that you are dehydrated and need to drink more fluids.
Call NHS 111 for advice if you are not able to drink more fluids or you are worried about your condition.
Diarrhoea
- Keep hydrated by drinking plenty of clear fluids (such as water or squash).
- Make sure you get enough rest.
- Eat small amounts regularly.
- Avoid greasy, fatty, and spicy foods.
- A simple pain reliever like paracetamol can help if you are in discomfort.
- Consider taking oral rehydration salts. Speak with your local pharmacist about these.
Call NHS 111 for advice if diarrhoea persists over a few days, or you are unable to tolerate any fluids, or you have bloody diarrhoea or there is bleeding from your bottom.
Constipation
- Gradually increase your fibre intake by including more fruits and vegetables, wholegrains, beans and pulses.
- Try eating fruits that are high in sorbitol, such as pear, peach, plums or prunes.
- Include some linseeds (available in most supermarkets) or psyllium husk (available from health food shops) in your diet. Start with a small amount mixed into foods or drinks, and gradually increase the amount over several days, up to 1 to 2 tablespoons per day. Make sure you take these with an extra glass of water.
- Make sure you move regularly throughout the day. Get regular activity, for example short walks.
Headaches
- Drink plenty of water.
- Take a simple pain relief medicine, such as paracetamol.
- Rest in a quiet place with dim lighting.
- Try relaxation strategies such as meditation, focusing on your breathing.
- Try gentle exercise.
- Apply hot or cold compresses to your head, neck.
- Ensure you are getting enough sleep.
Injection site reactions
These reactions can include redness, bruising, itching, swelling and pain. These tend to settle as your body gets used to the medicine. Until then you may wish to try a non drowsy antihistamine tablet or a local antihistamine cream which you can get from your local pharmacist.
Stop using the medicines and seek help from your GP, endocrinologist, NHS 111 or your nearest Emergency Department (A&E) if your rash gets worse, spreads, becomes redder or the pain is not tolerable.
Staying active
Regular exercise is essential to achieve the most weight loss. Exercise can help you lose weight and keep this weight off in the long term.
Aim for a minimum of 30 minutes of moderate intensity activity per day. You do not have to do this exercise in one go. You can break it down into 10 to 15 minute bursts. To lose weight, increase to 45 to 60 minutes per day. |
Moderate intensity physical activity includes anything where your body is moving and your breathing and heart rate increase, for example:
|
Include some muscle strengthening activities on at least 2 days of the week. This is important as it can limit the amount of muscle loss when you lose weight. It can also help to maintain your bone strength. |
Muscle strengthening activity includes:
|
See the More Information section below for online strength exercise resources.
Do not worry if your physical health means that you cannot reach the goal of 30 to 60 minutes per day.
Do what you can and aim to gradually increase the amount of moderate exercise you do.
Include exercise in your daily life in the following ways:
- Design a realistic exercise plan. It must fit with your lifestyle. If it does not, you will find it difficult to keep it going.
- Pick an activity you enjoy or try a new one.
- If you have not done regular activity before, start with gentle exercise and increase it slowly.
- Get support from a friend or partner who will encourage you and exercise with you.
- Use a step counter app or smart watch to track your activity and see if you can gradually increase the amount you are doing.
- If you have never enjoyed exercise, start by reducing your inactive time. For example you can spend less time watching television or using the computer. You can also use stairs instead of lifts or get off the bus 1 or 2 stops earlier than you need to.
- If you prefer to walk rather than go to the gym, you can try walking more quickly or gradually walking further and faster.
- For an outdoor activity, have a backup type of exercise that you can do when the weather is wet or cold.
- If mobility is difficult, try chair based, seated exercises (see More information below).
There are lots of free resources online that you can use for ideas or support (see More information below). You can also look for local clubs that run activities in your area.
Some GPs may be able to refer you to a local health centre for subsidised exercise sessions. These offer support from a personal trainer or gym instructor until you have the confidence to continue on your own.
Ask your GP for details of subsidised exercise sessions.
Other considerations
Smoking
We strongly advise you to stop smoking before starting weight loss medicines.
We understand that stopping can be difficult and you may need support. There are many support organisations available that we can discuss with you.
The aim of weight loss surgery is to improve your health, life expectancy and quality of life whereas smoking damages your health. Smoking is the single most detrimental activity that you can undertake to affect your health. It is the biggest cause of death and illness in the UK. |
Contraception and pregnancy with weight loss medicines
Losing weight can increase your fertility.
Do not use GLP 1RA medicines during pregnancy because their effects on an unborn baby are unknown. |
Discuss this with your GP or family planning clinic.
Hair loss
Hair loss is quite common with any significant weight loss. It is generally temporary and only lasts while you are losing weight rapidly.
Excess skin
- Significant weight loss can result in loose skin in some areas of your body (for example around your tummy, arms, legs and breasts).
- Some patients are not bothered by this and others find it upsetting. Occasionally, if skin folds are difficult to keep clean and dry, they become infected or sore.
- If you are worried about this, talk to other people. You can attend support groups to meet people who have had weight loss surgery.
- Plastic surgery is only way to effectively deal with loose skin, but it is not usually funded by the NHS.
Protein content of everyday foods
Use the following drop-down menus for guidance.
Food | Serving size | Calories (Kcal) | Protein (g) |
Baked white fish | 1 fillet (100g) |
72 |
16.6 |
Contact information
Kingston Healthy Weight Centre specialist dietitian
(email: khft.
or
Kingston Healthy Weight Centre specialist nurse
(email: khft.